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In addition, other epigenetic signals have been observed in mitochondria, in particular the interaction between mtDNA methylation and non-coding RNAs

Similar findings have been reported in the peripheral immune system, with peripheral blood mononuclear cells (PBMCs) from individuals with iPD exhibiting increased glycolytic activity, capacity, and reserve relative to controls [30]

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GSH is the major cellular antioxidant which maintaining redox homeostasis from the following two aspects: bind to ferrous iron in the labile iron pool (LIP) to prevent the iron-dependent oxidization (Hider and Kong, 2011) and as the substrate of GPX4-mediate lipid detoxification (Friedmann Angeli et al., 2014