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Early CKD stages often exhibit ABD, characterized by suppressed osteoblast activity due to uremic toxin-mediated inhibition of Wnt/-catenin signaling and elevated sclerostin levels ( 2.3 Vascular calcification Vascular calcification, a hallmark of CKD-MBD, arises from the osteogenic transformation of vascular smooth muscle cells (VSMCs) driven by hyperphosphatemia, inflammation, and uremic toxins

Cigarette smoke and biomass fuel-induced oxidative and aldehyde/carbonyl stress are closely associated with the progression and exacerbation of COPD

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Carnitine is indispensable for the mitochondrial beta oxidation of acyl-CoA esters, because it is transported with the acyl moiety, over the mitochondrial inner membrane