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17,18,19,20,21 This increase in synaptic glutamate occurs because of decreased tone and function of the extrasynaptic metabotropic glutamate autoreceptors, mGluR2/3, which normally inhibits synaptic glutamate release (this decreased inhibition leads to increased synaptic glutamate) 17,20 and decreased function of glial glutamate transporter-1, which causes reduced glutamate elimination from extracellular space resulting in spillover of synaptic glutamate

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Protein kinase Cdelta expression in breast cancer as measured by real-time PCR, western blotting and ELISA