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J Diabetes Res 2021: 9941791

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Abbreviations MetS: Metabolic syndrome IGF-1: Insulin-like growth factor CVD: Cardiovascular disease T2D: Type 2 diabetes RAS: Protooncogene protein P21 NAFLD: Non-alcoholic fatty liver disease OSA: Obstructive sleep apnea HDL: High density lipoprotein TG: Triglyceride PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase AKT: Protein kinase B GLUT: Glucose transporter FA: Fatty acid FFA: Free fatty ACID IGF-1R: IGF-1 receptor IGFBP: Insulin-like growth factor binding protein IRS: Insulin receptor substrate KO: Knock out LDL: Low density lipoprotein VLDL: Very low density lipoprotein GH: Growth hormone HOMA: Homeostasis model assessment ROS: Reactive oxygen species References Executive Summary of The Third Report of The

Using lipid nanoparticle-encapsulated siRNA to target and silence macrophage Cxcl2 markedly reduces myocardial neutrophil infiltration, diminishes inflammation, and reduces infarct size, concurrently demonstrating that aberrant macrophage chemotactic activity is a key target exacerbating post-inflammatory myocardial ischemic injury (33)