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Other TRAF6-activated pathways are associated, for example, with the induction of interferon production

In native physiology, the six IGFBPs perform several overlapping regulatory jobs: they extend the circulating half-life of IGF-1, they create a reservoir of hormone that can be released as needed, they modulate the amount of free peptide available to receptors, and in some contexts they exert IGF-independent effects of their own

Timing requirements for insulin/IGF-1 signaling in C