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Indeed, reducing isoleucine by two-thirds in a 21% protein diet was seen to improve multiple aspects of metabolic health and increase longevity substantially (33% median) in males and more modestly (7% median) in females relative to both a control diet and to a diet in which all amino acids were reduced by two-thirds (Yeh et al., 2023)

239 In murine models, enterotoxigenic strain colonization can induce colitis and promote colorectal carcinogenesis through the IL-17R, NF-B, and STAT3 pathways

Selenium-rich soils are widely distributed in the great plains of China, the United States, Canada, South America, Australia, India, and Russia [32]

In tumors with heterogeneous or low antigen expression, membrane-permeable payloads, including SN-38 and deruxtecan, are capable of diffusing into adjacent antigen-negative cells, thereby mediating a bystander effect that amplifies therapeutic coverage across spatially diverse tumor cell populations [47, 122, 124]