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The shared epitopes coded by human leukocyte antigen (HLA) alleles, non-HLA genes, epigenetic factors, and differentially glycosylated proteins are considered significant risk factors for progression of RA ( The advances in understanding its pathogenesis have fostered the development of new and improved therapeutics

Phosphorylated mTOR, ERK, AMPK, JNK, and p38 were specifically phosphorylated in the cells treated with AITC, with ERK, AMPK, and JNK being activated

Their combination with immunotherapy can enhance therapeutic efficacy [87]

For those in search of a higher-dose supplement, such as with B12 deficiency, 5000mcg per day can safely be used