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189 Management of DRPN focuses on optimizing glycemic control to prevent further nerve damage

doi: 10.1016/j.bbrc.2023.06.086 118 LippmannJPetriKFuldaSLieseJ

This is a centrally mediated effect PGE2 produced at peripheral inflammatory sites does not cross the blood-brain barrier, but circulating cytokines (IL-1, IL-6) induce COX-2 expression in brain endothelial cells, which produce PGE2 that acts on hypothalamic neurons