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K., Osswald, H

Here, by preventing the interaction of HIF1- with E3 ubiquitin ligases, both VEGF and CD31 expression was enhanced in ECs, coinciding with increased cell proliferation and migration collectively accelerating wound healing in diabetic mice 64

When SAMe is low, the remethylation of homocysteine to methionine is prioritized in the cell (instead of the transsulfuration pathway).[ref] Drains on methyl groups: About 40% of methyl groups are used for creatine synthesis, so when creatine levels are higher, it can reduce the need for methyl groups