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knockdown of the NNMT protein in the adipose tissue and liver using antisense oligonucleotides limited body weight gain in mice fed high fat diet, causing substantial fat mass reduction via increased energy expenditure

The PINK1/Parkin-mediated mitophagy is triggered when PINK1 is stabilized on the outer membrane of damaged mitochondria and recruites Parkin, an E3 ubiquitin ligase, followed by ubiquitination of mitochondrial proteins, which are then recognized by autophagy receptors [41]