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In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

(3) Tianqi LiuLiguo ZhangBeibei LuDeping LiYiyang Bo, et al (2022) Noninvasive and Efficient Peptide Delivery by a Novel Biocompatible Ionic Liquid ACS Sustainable Chemical Engineering, 2022, Volume 10, Issue 50, Pages 1661116623