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Vitamin E also prevents the metabolism of 12-LOX, a key mediator of glutamate-induced neurodegeneration, by preventing arachidonic acid from entering the catalytic site of 12-LOX and enabling vitamin E to effectively prevent neuronal degeneration (Khanna et al., 2003)

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Chen KG, Lacayo NJ, Durn GE et al (2002) Preferential expression of a mutant allele of the amplified MDR 1 ( ABCB 1) gene in drug-resistant variants of a human sarcoma

Enteric substances such as digested food fragments (amino acids, lipid fragments, and monosaccharides), intestinal microbial products, and exogenous toxins enter the liver via the portal vein (165)