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Molecules 30(19):3880 Hesami S, Hashemipour S, Shiri-Shahsavar MR, Koushan Y, Khadem Haghighian H (2019) Administration of Iranian propolis attenuates oxidative stress and blood glucose in type II diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

The PACES study investigated the addition of sildenafil 80 mg three times daily (four times the approved dose) to the treatment of 267 patients with PAH already receiving epoprostenol.85 After 16 weeks of treatment, improvements were seen in 6MWD, mean pulmonary arterial pressure, cardiac output, time to clinical worsening (TTCW) and quality of life (QoL) compared with placebo