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Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al

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Targeting VEGF/VEGFR to enhance effector T-cell function by antiangiogenic agents: VEGF is a crucial link between tumor growth and the immune response directed at that tumor since it promotes both neoangiogenesis and immunosuppression [78]

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