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It increases VEGF receptor activity to promote new blood vessel formation, enhances collagen synthesis and organization, activates the ERK1/2 signaling pathway for cell proliferation and migration, and modulates inflammatory responses to optimize healing conditions

However, B12 deficiency is relatively common, especially among people who are vegan, pregnant, anemic, or have any of a number of autoimmune diseases

For example, deficiencies in vitamins B6, B12, and folate can impair methylation processes, as these vitamins are required for the production of SAMe, a key methyl donor

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