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Nanoparticles can be engineered to cross the BBB via receptor-mediated transcytosis or adsorptive-mediated transcytosis, or to bypass the BBB altogether through alternative routes such as intranasal delivery, as described in-depth in Section 4.3

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However, in our study, we employed a fully hiPSC-derived model in which both microglia and neural organoids originate from the same donor, which provides a unique platform for investigating patient-specific aspects of HIV-1 neuropathogenesis and microglial responses

A novel method for assessing proximal and distal forelimb function in the rat: the Irvine, Beatties and Bresnahan (IBB) forelimb scale