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Notably, Ang-2 induced the upregulation of 2 -integrin on monocytes, which interacted with ICAM-1 expressed by endothelial cells and thereby facilitated the migration of monocytes, leading to accumulation of monocyte-derived macrophages in the TME (77)

We hypothesize that exposed hydrophobic core in PD-specific Syn variants not only drives aggregation and phase separation but also promotes promiscuous, non-functional binding to diverse proteins

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