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CT of the pelvis and lumbar spine were obtained, which showed numerous sclerotic lesions in the lower lumbar, pelvic, and bilateral femoral bones

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Of those, the gene encoding the glutathione peroxidase was highly expressed (Figure S3B)

Single nucleotide changes can have profound effects on the structure and function of FMO3, often leading to Trimethylaminuria ( Located on the endoplasmic reticulum, FMOs can oxygenate a wide variety of soft nucleophilic xenobiotics such as heteroatoms containing nitrogen, sulfur, boronic acids, selenium, and phosphorous functional groups (Ziegler, 1993)