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What we do not have is a dedicated primary prevention trial showing that treating healthy adults to apoB below, for example 0.6 g/L produces better health outcomes than current practice

In studies investigating the extension of gestational weeks in pregnant females with early-onset preeclampsia treated with metformin, metformin (1,0003,000 mg/d) significantly prolonged the expected time for treatment, and shortened the length of stay in the neonatal intensive care unit

Karl Steinmetz and Tomas Lankenau for their English review of the manuscript and Jess Ortiz Urbina for his generous help

This may lead to a bottleneck effect that should make TGR an attractive drug target