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[PubMed: 19695740] (Editorial regarding Yarema [2009] discussing the shortcomings of data on the optimal regimen of N-acetylcysteine therapy for acetaminophen overdose)

Although the theoretical limitations have been addressed, clinical experiments are necessary to validate the findings based on cell and animal studies

Although direct glutamate supplementation is clinically unfeasible due to its inherent neurotoxicity, Gln administration has emerged as a promising therapeutic strategy that supports neuronal energy metabolism while avoiding neurotoxic effects (Li et al

In the case of breast cells, the HER2 protein facilitates their normal growth and repair