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In a clinical trial of 71 women with mild to advanced photoaging, a GHK-Cu facial cream applied daily for twelve weeks significantly increased skin density and thickness while reducing fine lines, wrinkles, and laxity

Yet another article suggests 7-10 days refrigerated for some formulations

Don't Consume Refined Carbs If possible, do not consume refined carbs (foods like pasta, bread, and other grains) in abundance if you want to treat water retention