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Ligon B, Yang J, Morin SB, Ruberti MF, Steer ML

At the molecular level, chronic AOD9604 administration upregulates 3 adrenergic receptors in fat tissue, reversing obesityrelated suppression of these fatburning receptors [9]

M1 polarization depends on the IRF/STAT, LPS/TLR and NF-B/PI-3K pathways ( The cytokines IL-4, IL-10, IL-13, IL-33 and TGF- induce the polarization of macrophages towards an M2 phenotype