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Preeclampsia is classified as newly diagnosed hypertension accompanied by severe organ dysfunction, proteinuria, or uteroplacental dysfunction after 20 weeks of gestation (systolic blood pressure of 140 mmHg or diastolic blood pressure of 90 mmHg for a minimum of two occasions, spaced 4 hours apart)

Some of these biological drivers that accelerate cellular aging include: Mitochondrial dysfunction (your cells ability to produce energy efficiently) DNA damage (which accumulates over time and affects cell function) Cellular senescence ( old or damaged cells that stop dividing but dont die off) Oxidative stress (an imbalance between free radicals and your antioxidant defenses) Chronic inflammation (low-grade inflammation that disrupts repair and immunity) Impaired tissue repair (a reduced ability to regenerate and heal) Hormonal changes (declines in key hormones that regulate metabolism, cognition, and more) Immune system decline (reduced ability to defend against threats and remove cellular waste) These internal biological mechanisms form a feedback loop that accelerates aging from the inside out

All mice were approximately 89 weeks old at the beginning of the experiment and naive

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