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Integrin complexes, such as integrin v3, 41 and 5, play important roles in the attraction and adhesion of breast tumor cells to the bone (103105)

doi: 10.1016/j.autrev.2020.102527 59 NaculLOBoyleSPallaLNaculFEMudieKKingdonCCet al

Therefore, imbalances in copper homeostasis are associated with a variety of diseases, including diabetes, neurological disorders, and cancer (63)

These interactions can trigger a series of immunoregulatory responses, involving both innate and adaptive immune systems and including cross-presentation of antigens, activation of CD 8 + T cells and CD 4 + T cells, phagocytosis, complement-mediated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)