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In one instance, he says, he saw site workers simply pour containers of carbon tetrachloride a refrigerant and aerosol propellant directly into the canals

The primary pathophysiological mechanism involves the rupture of small cerebral blood vessels or microaneurysms, often resulting from chronic hypertension, with sudden blood pressure spikes frequently acting as triggers [4]

in Handbook of Proteolytic Enzymes 2nd edn

These receptors are highly concentrated in adipose tissue (particularly visceral fat and brown fat) but have limited expression in most other tissues in adult humans