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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Ladang A., Beaudart C., Reginster J.Y., Al-Daghri N., Bruyre O., Burlet N., Cesari M., Cherubini A., da Silva M.C., Cooper C., et al

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ROS includes molecules such as superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), and hydroxyl radicals (OH), 101,102 which can impair mitochondrial function by damaging mtDNA, proteins, membrane lipids, and other cellular components

One (NCT03178929) is designed to investigate SAMe treatment (2000 mg, P.O.) in HCC patients (Barcelona Clinic Liver Cancer 0/A) after radical treatment, where tumor recurrence is the endpoint