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These proteins, known as flippases or FIC1, are involved in maintaining an asymmetric distribution of phospholipids across the canalicular membrane of hepatocytes, thereby protecting the canalicular membrane from hydrophobic BAs and maintaining its integrity

GRK3 expression in cardiac myocytes progressively increases in 6-, 12-, and 24-month-old spontaneously hypertensive heart failure rats and is significantly higher than in control rats [71]