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Choose Vitamin B12 Injections If: Deficiency is severe Neurological symptoms are present Digestive absorption is impaired Rapid improvement is required Choose Oral Supplements If: Deficiency is mild Absorption is intact You prefer a non-invasive method Long-term maintenance is needed There is no universal answer to B12 injections vs oral supplements which is better?"

However, the findings of this meta-analysis should be explained cautiously due to remarkable heterogeneity of the included IVF patients (227)

Statements Author contributions WC: Methodology, Writing original draft, Writing review & editing

Key takeaways: The MTHFR enzyme converts folate (vitamin B9) to its active form, 5-MTHF