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Continuous eligibility beyond the statutory requirement for children was also eliminated as a waiver option in July 2025

They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

Ashmarin, I.P., Nezavibatko, V.N., Myasoedov, N.F., Kamensky, A.A., Grivennikov, I.A., Ponomareva-Stepnaya, M.A., Andreeva, L.A., Kaplan, A.Y., Koshelev, V.B., and Ryasina, T.V., Zh

Collectively, the scientific data on mitragynine and 7-hydroxymitragynine suggest that kratom tea might indeed be an effective alternative to opioids against pain