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Stacking Protocols Critical: Community sources warn against combining multiple senolytics simultaneously and describe allowing adequate recovery between senolytic courses (minimum 4-6 weeks), running each compound individually first, and monitoring bloodwork (CBC, CMP, inflammatory markers) between courses

Due to the low number of trials with a low risk of bias and trials that implemented energy restriction alongside their intervention, we did not perform pre-specified sensitivity analyses with trials with a low risk of bias and energy restriction

mRNA vaccines can be produced through in vitro transcription, which precludes the need for cells and their associated regulatory hurdles 43

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