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doi: 10.1089/ars.2010.3098

p16 is crucial for maintaining senescence by regulating Rb protein phosphorylation to inhibit cell division 9

In addition, 2-MNG was recently shown to be the first topical biological active to significantly and visibly reduce persistent, long-lasting pigmentation induced by high-energy visible (HEV) light, demonstrating a rapid and dose-dependent effect [123]