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Their uniqueness lies in achieving therapeutic goals by inhibiting NSP activation processes rather than directly antagonizing activated NSPs, establishing entirely new therapeutic avenues for neutrophil-mediated inflammatory respiratory disease management ( From drug development progress perspectives, brensocatib as the pioneering drug in this field has achieved remarkable results in clinical development

Furthermore, the expression of genes associated with mitochondrial biogenesis, including PGC-1, Nrf1, NRF2, and TFAM, was observed to have decreased in brain tissue samples from AD patients (Qin et al., 2009

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