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Description

Age-associated declines in renal and hepatic function, coupled with changes in body compositionsuch as increased fat-to-lean mass ratiocan modify drug distribution and clearance

Sinnott VB, Otto CM

Since NNMT expression is directly determined by the NNMT gene, in our previous works, nineteen SNPs in the NNMT DNA sequence were selected as tagSNPs using Haploview software (Haploview 4.2) to observe the association between NNMT gene polymorphisms and obesity [29] and hyperlipidemia [30]