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For many people, the answer isn't necessarily "either/or" but rather "both." Because they work through different mechanismsone from the inside and one from the outsidethey can be quite complementary

Kamiyama E, Nakai D, Mikkaichi T, Okudaira N, Okazaki O

APAP toxicity could be due to the ingestion of a single overdose or too frequent doses with therapeutic intent ( It has been documented that PA administration provided protection through metal chelation and its antioxidant properties ( The present data based on APAP-induced hepatotoxicity in mice identified that PA treatment for 7 days at a dose of 200 mg/kg/day has critical actions in modulating APAP-induced liver toxicity in mice