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doi: 10.1007/s00203-022-02899-6, 4 AkmukhanovaN

G'79 Northrop Grumman Corporation Eileen Barrett Notarianni, MBA SPHR '91, P'22 Robert J

Further studies are necessary to clearly delineate the major NAD + biosynthetic pathways and NAD + consumption routes during macrophage phenotypic transition to determine whether the observed decline in NAD + levels depends on context and time and to determine the molecular mechanisms through which NAD + levels alter macrophage polarization states and functions

1 Introduction CKD, which is defined by the gradual loss of kidney function and progressive structural damage, has become a pressing public health concern globally, including in China