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This advancement in bone age can result in a slightly shorter adult height, although several studies report comparable final stature between children with and without obesity [75, 76] Despite acting through opposite biological pathways, growth attenuation is also observed in pediatric undernutrition, though typically to a much greater extent

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For example, in humans, TLR9 is primarily expressed in B cells, whereas in mice, it can be found in B cells, monocytes, macrophages, and plasmacytoid DCs (pDCs) (246)