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Birth Defects: Original Article Series 1987;23(5A) 193-198 173

10.1016/j.cell.2011.02.018 [DOI] [PMC free article] [PubMed] [Google Scholar] 78.Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, et al

EGB also boosted HO-1 expression, transactivity, and nuclear Nrf-2 levels

That might not sound catastrophic, but when you are on a carefully calibrated dosing protocol , a 10 percent reduction means your 0.5 mg dose is really delivering 0.45 mg