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Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib

The treatment itself typically takes 30-60 minutes and is administered by a skilled professional

Role of the Keap1-Nrf2 System in Cytoprotection against Oxidative Stress To protect cells from harmful oxidative stress, the transcription factor Nrf2 plays an integrative role in inducing the expression of genes encoding enzymes involved in antioxidant (e.g., glutathione and NADPH) production and the reduction in pro-oxidants (e.g., heme and quinonoids, Figure 2) [14,18]