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New In Vivo Animal Model to Create Intervertebral Disc Degeneration and to Investigate the Effects of Therapeutic Strategies to Stimulate Disc Regeneration

doi: 10.1016/S0968-0896(01)00038-4

This multi-level, multi-angle evidence chainfrom clinical observation to cell models and animal interventionscollectively supports ferroptosis as a critical link in OA cartilage pathology, with GPX4 dysfunction permeating this process