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16 Selenium, identified as a toxic catalyst in 1817, was later found to be an essential component of the glutathione peroxidase (GPX) family, with GPX1 becoming widely accepted as a novel peroxidase in 1957

Whereas regulatory T cells (Tregs) mainly depend on lipid oxidation as the main source of metabolism, ROS produced during oxidative metabolism affect the differentiation of CD4 + T cells through various mechanisms ( in vivo , oxidative stress, and the harmful effects of oxidative stress on physiological functions

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