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Responses were used to calculate K D , k on , and k off values using a 1:1 global fitting with R max unlinked by sensors and a steady state analysis of a response curve was used to calculate K D and nominal R max values

The ADC showed synergism with fludarabine, an agent used in many conditioning regimens, in cytotoxicity of AML cell lines, further indicating its potential for inclusion in RIC

10.1097/mca.0000000000000243 38 ChengS.WuJ.PeiY.TongH.FanM.XiangQ.et al (2023)

The combination of suppressed T3 and T4 levels with elevated TSH indicates a specific endocrine disruption that, when paired with the evidence of cellular injurynamely, the tissue upregulation of pro-apoptotic markers (Caspase-3 and Bax) and oxidative stress indicators like MDAforms a highly suggestive profile of GLP-induced cellular demise