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Dysregulation of the tyrosinase enzyme is the main cause of melanogenesis inhibition Hyperpigmentation is the darkening or increase in the natural color of the skin usually due to an increased deposition of melanin (hypermelanosis) Less frequently, it may be caused by the deposition in the dermis of endogenous or exogenous pigments, such as hemosiderin, iron, or heavy metals The excess of melanin in the basal and suprabasal layers of the skin is due to either an abnormally high number of melanocytes or a normal melanocyte population

We're all UK Chartered Physiotherapists with Masters Degrees related to Sports & Exercise Medicine or at least 10 years' experience in the field

Additionally, tips to reduce water retention may also help

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25