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Hodgson N, Waly MI, AlFarsi Y, AlSharbati MM, Al-Farsi OA, Ali A, Ouhtit A, Zang T, Zhou ZS, Deth RC (2014) Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman

Figure 3 3.1 TLR-nuclear factor kappa B signaling pathway As one of the earliest identified PRR families, TLRs comprise 10 members in humans (TLR1-10) and 12 in mice (TLR1-9, 11-13) ( Simultaneously, the IRAK-TRAF6 complex activates mitogen-activated protein kinase kinase (MKK) cascades, thus leading to activation of activator protein 1 (AP-1), which is another critical transcription factor in inflammation ( Figure 4 )

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