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However, in the negative ion mode, although the TLYYH cluster shifted toward the NC group, it remained partially overlapping with the DSS group, indicating distinct yet incompletely resolved metabolic differences among the three groups

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Via high-butyrate diet intervention and adoptive transfer experiments, it confirmed that a high-butyrate diet can induce the differentiation of follicular Tregs through HDAC inhibition, suppress the production of type II collagen (CII)-specific autoantibodies, and reduce joint swelling and bone erosion