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Description

Waglerin-1 (H-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys-His-Pro-Pro-Cys-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH), for example, is a peptide isolated from the venom of the temple viper, Tropidolaemus wagleri

First, it highlights the unique role of COFs in reversing the immunosuppressive tumor microenvironment-through intrinsic enzyme-mimicking activities (such as catalase-like or glutathione peroxidase-like functions) or by carrying functional components-to alleviate hypoxia and deplete GSH (Section 5)