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It manifests by the failure to induce transcription of progesterone-target genes despite adequate hormonal bioavailability [36]

Transcription factors act as key regulatory nodes, integrating upstream signals with downstream responses: DREB/CBF proteins mediate ABA-independent pathways, whereas NAC, MYB, WRKY, and bZIP families regulate ABA-dependent networks controlling aquaporins, osmoprotective metabolism, and antioxidant capacity (Sornaraj et al

Most researchers report that meaningful changes in autoimmune-related symptoms require 4 to 12 weeks of consistent use

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