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Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

PKG is a cGMP-dependent protein kinase, indicating that PKG may be a potential target for G6PD to promote VSMC proliferation

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