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5 Future research directions 5.1 Targeted delivery systems To address challenges such as poor water solubility, insufficient targeting, and low bioavailability associated with phytochemicals and active components of TCM in the prevention and treatment of CVD and cognitive impairment, researchers have developed diverse nano-delivery systems that significantly enhance therapeutic efficacy and targeting specificity

Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, et al

The sample size was determined as the minimum number of animals required to detect the desired effect size with a minimum of 80 % power

105 to110]), carbamazepine (105 [95% C.I