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The simplicity of the protocol is appealing, but the daily commitment and fasting requirement make it more demanding than a once-weekly injection

Physiologic GH replacement typically results in IGF-1 levels within or near the reference range, not the sustained high exposures that drive mitogenesis in vitro

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In vivo MRI scanning showed that mice tail vein injected with BEAGA-PDHD or ApoE-PDHD exhibited no appreciable increase in T1-weighted MRI intensity in the sectional view of transverse or coronal plane, whereas mice receiving BEAGA/ApoE-PDHD showed significantly enhanced T1-weighted MRI intensities in tumor site over 24 h postinjection (Fig