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For example, when LNPs containing FLuc-encoding mRNA were administered intramuscularly or subcutaneously to BALB/c mice, the translation efficiency of dual-modified mRNAs (m 5 C + and m 5 C + m 1 ) was lower than that of mRNAs containing only a single modification type

The majority of antidepressant drugs commonly inhibit neural reuptake of 5-HT and/or noradrenaline, and increase the synaptic levels of 5-HT and/or noradrenaline ( 2 and 5-HT 3 receptors without affecting 5-HT or noradrenaline transporters ( Figure 1 )